A Healthesystems publication

Summer 2017
How Off-Label Prescribing Drives a Claim Off Course

Off-label prescribing, or the prescribing of drug therapies outside their approved use, occurs commonly with certain medications in workers’ comp. The U.S. Food and Drug Administration (FDA) is now also considering granting drug manufacturers new leeway to promote off-label use of their products, which could further impact prescribing trends. While off-label use of drug therapies is sometimes medically warranted, there are many examples of it in workers’ comp that are ineffective and can present a safety risk to the patient.

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SOURCES

1 -Centers for Disease Control and Prevention. Injury Prevention & Control: Opioid Overdose – Fentanyl. https://www.cdc.gov/drugoverdose/opioids/fentanyl.html Accessed March 14, 2017.
2 -Actiq [package insert]. North Wales, PA: Teva Pharmaceuticals USA, Inc.; December 2016.
3 -Fentora [package insert]. North Wales, PA: Teva Pharmaceuticals USA, Inc.; December 2016.
4 -Subsys [package insert]. Chandler, AZ: Insys Therapeutics, Inc.; December 2014.
5 -Lipton B and Colon D. Workers compensation and prescription drugs: 2016 update. NCCI Research Brief. https://www.ncci.com/Articles/Documents/II_ResearchBrief_WC_Prescription_Drugs.pdf Accessed February 27, 2017.
6 -Soma [package insert]. Somerset, NJ: Meda Pharmaceuticals; January 2013.
7 -Hegmann KT, Weiss MS, Bowden K, et al. ACOEM Practice Guidelines: Opioids for treatment of acute, subacute, chronic, and postoperative pain. J Occup Environ Med. 2014;56:e143-e159.
8 -Edlund MJ, Martin BC, Russo JE, et al. The role of opioid prescription in incident opioid abuse and dependence among individuals with chronic noncancer pain: the role of opioid prescription. Clin J Pain. 2014;30(7):557-64.
9 -Dunn KM, Saunders KW, Rutter CM, et al. Opioid prescriptions for chronic pain and overdose: a cohort study. Ann Intern Med. 2010;152(2):85-92.
10 -Gomes T, Mamdani MM, Dhalla IA, et al. Opioid dose and drug-related mortality in patients with nonmalignant pain. Arch Intern Med. 2011;171(7):686-91.
11 -Lavin RA, Tao XG, Yuspeh L, et al. Impact of the combined use of benzodiazepines and opioids on workers’ compensation claim cost. J Occup Environ Med. 2014;56:973-8.
12 -Healthesystems findings, 2017.
13 -Tao X, Lavin RA, Yuspeh L, et al. The association of the use of opioid and psychotropic medications with workers’ compensation claim costs and lost work time.
14 -ACOEM. Drug formularies in workers’ compensation systems: A position statement of the American College of Occupation and Environmental Medicine. August 2016.
15 -CNBC. The pain killer: a drug company putting profits above patients. http://www.cnbc.com/2015/11/04/the-deadly-drug-appeal-of-insys-pharmaceuticals.html. Accessed February 28, 2017.
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